ANALYSIS OF ANALGESIC GROUPS IN PHARMACEUTICAL PREPARATIONS USING UV SPECTRO

Main Article Content

Siti Arina Mardiana
Delta Happy Friantina
Syarifa Risqina Achmad
Ema Aulia Fikasari
Zalfa Zahiyah Putri
Prillya Posma Meldawati Tambunan

Abstract

Supervision and quality inspection of pharmaceutical preparations is carried out to ensure that the ingredients in medicinal preparations have the specified quality and quantity and follow standard analysis procedures. One form of medication is generic mefenamic acid tablets. To determine the mefenamic acid content of tablets, the ultraviolet spectrophotometric method can be used. Before performing assay analysis, the analytical method must be validated to ensure that the method meets the requirements for use. The aim of this study was to determine the validity of the ultraviolet spectrophotometry method for evaluating the determination of mefenamic acid levels in generic tablets based on certain parameters. This research is descriptive and validates the ultraviolet spectrophotometry method. Monitoring and quality inspection of pharmaceutical preparations is carried out to ensure that the ingredients in medicinal preparations have the specified quality and quantity and follow standard analysis procedures.

Article Details

How to Cite
Mardiana, S. A., Friantina, D. H., Achmad, S. R., Fikasari, E. A., Putri, Z. Z., & Tambunan, P. P. M. (2024). ANALYSIS OF ANALGESIC GROUPS IN PHARMACEUTICAL PREPARATIONS USING UV SPECTRO. Medic Nutricia : Jurnal Ilmu Kesehatan, 9(4), 91–100. https://doi.org/10.5455/nutricia.v9i4.8902
Section
Articles
Author Biographies

Siti Arina Mardiana, Semarang State University

Pharmaceutical laboratory, Department of Pharmacy, Semarang State University

Delta Happy Friantina, Semarang State University

Pharmaceutical laboratory, Department of Pharmacy, Semarang State University

Syarifa Risqina Achmad, Semarang State University

Pharmaceutical laboratory, Department of Pharmacy, Semarang State University

Ema Aulia Fikasari, Semarang State University

Pharmaceutical laboratory, Department of Pharmacy, Semarang State University

Zalfa Zahiyah Putri, Semarang State University

Pharmaceutical laboratory, Department of Pharmacy, Semarang State University

Prillya Posma Meldawati Tambunan, Semarang State University

Pharmaceutical laboratory, Department of Pharmacy, Semarang State University

References

Z. Alfian, H. Marpaung, M. Taufik, R. Harahap, and C. Simanjuntak, “Detection and identification of morphine in blood of male white rats (rattus norvegicus) by ultraviolet-visible spectrophotometry,” J. Phys. Conf. Ser., vol. 1116, no. 4, 2018, doi: 10.1088/1742-6596/1116/4/042004.

N. Karnakar, “Machine Translated by Google Machine Translated by Google Pengembangan metode analisis dan validasi natrium diklofenak dengan spektroskopi UV-visibel menggunakan metode AUC,” 2020.

S. Naveed and F. Qamar, “UV spectrophotometric assay of Diclofenac sodium available brands,” J. Innov. Pharm. Biol. Sci., vol. 1, no. 3, pp. 92–96, 2014.

D. Christin, A. Putri, M. R. Gani, and F. D. Octa, “Chemometrics-Assisted UV Spectrophotometric Method for Simultaneous Determination of Paracetamol and Tramadol in Divided Powder Dosage Form,” Int. J. Pharm. Res., vol. 13, no. 01, pp. 1901–1907, 2020, doi: 10.31838/ijpr/2021.13.01.075.

Nofita, R. Dayanti, Tutik, and Supardi, “Penetapan Kondisi Optimum Pengujian Kadar Parasetamol Dan Kafein Dengan Kromatografi Cair Kinerja Tinggi,” J. Farm. Malahayati, vol. 1, no. 2, pp. 96–106, 2018.

P. Mehta, C. Sharma, D. Nikam, and M. Ranawat, “Development and Validation of Related Substances Method by HPLC for Analysis of Naproxen in Naproxen Tablet Formulations,” Int. J. Pharm. Sci. drug Res., vol. 4, no. 1, pp. 63–69, 2012.

R. E. Tarigan, N. Sajida, and C. Surbakti, “Advanced UV Spectrophotometry-Classical Least Squares Determination of Paracetamol, Phenylpropanolamine HCl, and Chlorpheniramine Maleate in Tablet Dosage Form,” Int. J. Sci. Technol. Manag., vol. 5, no. 4, pp. 985–990, 2024, doi: 10.46729/ijstm.v5i4.1150.

V. Siva Rama Krishna, S. Belemkar, and R. N. Tiwari, “RP-HPLC method development and validation of etodolac and paracetamol in tablet dosage form,” Int. J. PharmTech Res., vol. 6, no. 2, pp. 775–782, 2014.

Asiva Noor Rachmayani, “DETERMINATION OF IBUPROFEN TABLETS IN WISTAR RAT PLASMA MATRIX BY HPLC,” p. 6, 2015.

A. F. Pulungan, “… Dan Kofein Secara Spektrofotometri Ultraviolet Dengan Metode Principal Component Regression Dan Rasio Absorbansi Tahun …,” JIFI (Jurnal Ilm. Farm. Imelda), vol. 2, no. 2, pp. 82–88, 2019, [Online]. Available: https://jurnal.uimedan.ac.id/index.php/JURNALFARMASI/article/view/203

S. Musiam and R. Alfiian, “Validasi Metode Spektrofotometri UV pada Analisis Penetapan Kadar Asam Mefenamat dalam Sediaan Tablet Generik,” J. Ilm. Ibnu Sina, vol. 2, no. 1, pp. 31–43, 2017.

G. Motan and A. Puia, “Studies of different types of aspirin by spectrophotometric methods,” Acta Chem. Iasi, vol. 22, no. 2, pp. 155–164, 2014, doi: 10.2478/achi-2014-0013.

D. Muldianah, S. Sulastri, A. Fatharani, D. A. Nurdimayanthi, D. S. Rahmawati, and H. Fadhilah, “Metode Analisis Paracetamol (Acetaminophen) dalam Darah, Plasma, Dan Serum Manusia,” Comserva, vol. 2, no. 1, pp. 1–12, 2022, doi: 10.59141/comserva.v2i1.202.

H. S. Ramadan, R. A. A. Salam, G. M. Hadad, F. Belal, and M. M. Salim, “Eco-friendly simultaneous multi-spectrophotometric estimation of the newly approved drug combination of celecoxib and tramadol hydrochloride tablets in its dosage form,” Sci. Rep., vol. 13, no. 1, pp. 1–12, 2023, doi: 10.1038/s41598-023-38702-9.

G. P. Tulandi, S. Sudewi, and W. A. Lolo, “Validasi Metode Analisis Untuk Penetapan Kadar Parasetamol Dalam Sediaan Tablet Secara Spektrofotometri Ultraviolet,” PHARMACON J. Ilm. Farm., vol. 4, no. 4, pp. 168–178, 2015.

A. Siswanto, A. Fudholi, A. K. Nugroho, and S. Martono, “Validasi Metode HPLC untuk Penetapan Aspirin dan Asam Salisilat dalam Plasma Kelinci ( Lepus curpaeums ) secara Simultan Validation of A High Performance Liquid Chromatography Method for The Simultaneous Determination of Aspirin and Salisylic Acid In Rabb,” J. Kefarmasian Indones., vol. 6, pp. 68–78, 2016.

L. Daerah, K. Secara, S. Ultraviolet, H. Rivai, and B. Chandra, “Pengembangan dan Validasi Metode Analisis Ketoprofen Tablet dengan Metode Absorbansi dan Luas

L. K. El-Khordagui, “Effect of sodium salicylate on the solution properties of sodium dodecyl sulphate,” Int. J. Pharm., vol. 83, no. 1–3, pp. 53–58, 1992, doi: 10.1016/0378-5173(82)90007-2.

N. I. Akib, M. H. Sahumena, Y. Dawu, V. Aspadiah, I. Hafizah, and H. Ritonga, “Optimasi Kadar Fenilbutazon dalam Pembawa Vesikular Etosom,” vol. 7, no. April, pp. 88–96, 2020.

M. Rena, L. Nurlaeli, and L. Suryanti, “Analisis Kandungan Parasetamol pada Jamu Pegal Linu di Wilayah Cilodong dengan menggunakan Spektrofotometri Uv-Vis,” Open Access Jakarta J. Heal. Sci., vol. 3, no. 7, pp. 1327–1334, 2024, doi: 10.53801/oajjhs.v3i7.288.

A. Diningsih, E. S. Hasibuan, N. A. Rangkuti, H. Y. Harahap, and A. Syahadat, “Analisis Kadar Parasetamol Dalam Sediaan Tablet Dengan Menggunakan Spektrofotometer Uv-Visible,” Forte J., vol. 4, no. 2, pp. 354–359, 2024, doi: 10.51771/fj.v4i2.914.