PERAN MIKROBIODATA USUS DALAM PATOGENESIS PENYAKIT PERADANGAN: TINJAUAN LITERATUR
Article Sidebar
Usus,
Patogenesis,
Penyakit,
Peradangan
Main Article Content
Abstract
Usus adalah organ panjang dan berkelok-kelok yang merupakan bagian penting dari sistem pencernaan manusia. Bermula dari lambung, usus terbagi menjadi dua bagian utama ialah usus halus dan usus besar. Ketidakseimbangan dalam komposisi dan fungsi mikrobiota usus dapat memicu peradangan dan berkontribusi pada perkembangan berbagai penyakit peradangan, seperti penyakit radang usus (IBD), rheumatoid arthritis, multiple sclerosis, penyakit hati berlemak non-alkohol (NAFLD), obesitas, dan diabetes tipe 2. Penelitian ini bertujuan untuk memahami perubahan komposisi mikrobiota usus memengaruhi perkembangan penyakit peradangan serta menyelidiki mekanisme yang mendasari mikrobiota usus berkontribusi pada proses peradangan dalam tubuh. Metode yang dipakai ialah metode studi pustaka. Data dari berbagai sumber tertulis seperti buku, jurnal ilmiah, dan laporan penelitian dianalisis untuk memahami secara mendalam topik penelitian. Temuannya ialah mikrobiota usus dapat berkontribusi pada patogenesis penyakit peradangan melalui beberapa mekanisme, termasuk peningkatan permeabilitas usus (leaky gut), produksi sitokin pro-inflamasi, aktivasi inflammasome, produksi metabolit berbahaya, dan interaksi dengan sistem imun.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Burisch J. Crohn's disease and ulcerative colitis. Occurance, course and prognosis during the first year of disease in a European population-based inception cohort. Dan Med J. 2014;61(1):B4778-B14778.
Erben U, Loddenkennper C, Spieckermann S, Heimesaat MM, Siegmund B, Kuehl AA. Histomorphology of intestinal inflammation in inflammatory bowel diseases (IBD) mouse models and its relevance for IBD in men. Int J Clin Exp Med. 2016;9:408-42.
Mustika S, Triana N. The Prevalence, Profile, and Risk Factor of Patients with Ulcerative Colitis at Dr. Saiful Anwar Malang General Hospital. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy. 2016;17(1):16-20
Rios JL., Bomhof MR., Reimer RA., Hart DA., Collins KH., Herzog W. (2019). Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-inducedobesity. Scientific Reports, 9(1),3893.
Frank DN., Amand ALS., Feldman RA., Boedeker EC., Harpaz N., Pace NR. (2007). Molecularphylogenetic characterization of microbial community imbalances in human inflamatory bowel diseases. Proceedings of the National Academy of Sciences of the United States of America, 21(104), 13780–13785. https://doi.org/10.1073/pnas.0706625104
Zhang W., Moskowitz RW., Nuki G., Abramson S., Altman RD., Arden N., Bierma-Zeinstra S., Brandt KD., Croft P., Doherty M., etal. (2008). OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence based, expert consensus guidelines. Osteoarthritis and Cartilage, 16(2), 37–62.
Guss JD., Ziemian SN., Luna M., Sandoval TN., Holyoak DT., Guisado GG., Roubert S., Callahan R.L, Brito IL, vanderMeulen MCH, etal. (2019). The effects of metabolic syndrome, obesity, and the gut microbiome on load- induced osteoarthritis. Osteoarthritis Cartilage, 27(1),129–39
Baker KR., Matthan NR., Lichtenstein AH, Niu J., Guermazi A., Roemer F., Grainger A., Nevitt MC., Clancy M., Lewis CE,. etal. (2012). Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis and Cartilage, 20(5), 382–7.
Heidegger, S., Van den Brink MR., Haas T., Poeck, H. 2015. The role of patternrecognition receptors in graft-versushost disease and graft-versusleukemia after allogeneic stem cell transplantation. Frontiers in immunology 5: 337.
Sugiyono. Metode penelitian kuantitatif, kualitatif, dan R&D. Bandung: Alfabeta. 2018.
Johansson, M., Larsson, J. H., dan Hansson, G. 2011. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interacttions. Proceedings of the National Academy of Sciences USA 108(1): 4659-4665.
Maranduba, C.M.D.C., Castro, S.B.R.D., Souza, G.T.D., Rossato, C., Guia, F.C.D., Valente, M.A.S., Rottore, J.V.P., Maranduba, C.P., Souza, C.M.D., Carmo, A.M.R.D., Macedo, G.C. dan Silva, F.D.S. 2015. Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis. Hindawi Publishing Corporation. Journal of Immunology research 2015.
Alfan M. Dampak tempat pembuangan akhir (TPA) sampah kebon kongok terhadap gangguan kesehatan masyarakat Desa Suka Makmur Kecamatan Gerung Kabupaten Lombok Barat Tahun 2017 [Skripsi]. Mataram: Fakultas Ilmu Tarbiyah dan Keguruan UIN; 2017.
Bezirtzoglou E, Tsiotsias A, Welling GW. Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe [Internet]. 2011;17(6):478–82. Available from: http://dx.doi.org/10.1016/j.anaerobe.2011.03.009
Niegawa T, Kimitaka Takitani RT, Manabu Ishiro, Yuichi Kuroyanagi, Keisuke Okasora YM, Matsuda T, Tamai and H, Department. Evaluation of uric acid levels, thyroid function, the Society for Free Radical Research Japan 1880 50860912-0009 10.3164/j5cb .17-55 JJCBN Kyj bn17-5 Original Article c oto, Japan ournal of Clinical Biochemistry and Nutrition and anthropometric parameters. J Clin Biochem Nutr. 2018;62(2):179–86.
Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, et al. Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors. Cell Host Microbe [Internet]. 2019;25(2):324-335.e4. Available from: https://doi.org/10.1016/j.chom.2019.01.011
Verhasselt V. Oral tolerance in neonates: from basics to potential prevention of allergic disease. Mucosal Immunol. 2010 Jul;3(4):326–33.
Perna S, Ilyas Z, Giacosa A, et al. Is Probiotic Supplementation Useful for the Management of Body Weight and Other Anthropometric Measures in Adults Affected by Overweight and Obesity with Metabolic Related Diseases? A Systematic Review and Meta-Analysis. Nutrients. 2021;13(2):666. doi:10.3390/nu13020666
Engstrom I. Inflammatory bowel disease in children and adolescents: mental health and family functioning. Journal of pediatric gastroenterology and nutrition. 1999;28(4).
Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell host & microbe. 2007;2(2):119-29.